NaturallyoccurringflavonoidfoundinGingkobilobaandredwinesthatactivatesthemitochondrialCa2+uniporter(EC50=7μM).Inducescaspase-9-mediatedapoptosisinavarietyofcancercelllinesviadownregulationofpolo-likekinase1(PLK1)expression.Exhibitsantioxidantactivityandattenuatesosteoclasticbonereabsorptioninvitro.AlsoblocksEGF-inducedhistoneH3Ser10phosphorylationinmouseepidermalJB6C141cells.
KaempferolisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 286.24 |
Formula | C15H10O6 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 520-18-3 |
PubChemID | 5280863 |
InChIKey | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
Smiles | O=C2C1=C(O)C=C(O)C=C1OC(C3=CC=C(O)C=C3)=C2O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.62 | 100 | |
ethanol | 28.62 | 100 |
Thefollowingdataisbasedontheproductmolecularweight286.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.49mL | 17.47mL | 34.94mL |
5mM | 0.7mL | 3.49mL | 6.99mL |
10mM | 0.35mL | 1.75mL | 3.49mL |
50mM | 0.07mL | 0.35mL | 0.7mL |