Selectiveinhibitorofthebreastcancerresistanceprotein(BCRP)multidrugtransporter(IC50valuesare0.59and1.39μMinPheoAandHoechst33342assaysrespectively).DisplaysnoinhibitoryactivityagainstP-gporMRP1.
KS176isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 405.4 |
| Formula | C22H19N3O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1253452-78-6 |
| PubChemID | 49779726 |
| InChIKey | LTWQQWSXYYXVGA-UHFFFAOYSA-N |
| Smiles | OCCC1=CC=C(NC(C2=C(NC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=CC=C2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.54 | 100 |
Thefollowingdataisbasedontheproductmolecularweight405.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.33mL | 24.67mL |
| 5mM | 0.49mL | 2.47mL | 4.93mL |
| 10mM | 0.25mL | 1.23mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |



