CorrectsF508del-CFTRtrafficking;increasestheamountoffunctionalCFTRattheplasmamembrane(~75%).ShowntoinhibitPDE5activity.
| M.Wt | 422.33 |
| Formula | C19H17Cl2N3O2S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 774549-97-2 |
| PubChemID | 1241327 |
| InChIKey | GIEHIZKCIZLXLF-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.23 | 100 | |
| ethanol | 4.22 | 10 |
Thefollowingdataisbasedontheproductmolecularweight422.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.84mL | 23.68mL |
| 5mM | 0.47mL | 2.37mL | 4.74mL |
| 10mM | 0.24mL | 1.18mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |



