Cryptochromeprotein(CRY)stabilizer;blocksproteasome-mediateddegradationofCRY1andCRY2.LengthenscircadianperiodinmouseNIH-3T3fibroblastswithoutalteringcaseinkinaseactivity.Repressesglucagon-inducedhepaticgluconeogenesisthroughtheinductionofPck1andG6pcexpression.
KL001isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 398.48 |
Formula | C21H22N2O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 309928-48-1 |
PubChemID | 2888648 |
InChIKey | OQAFDLPAPSSOHY-UHFFFAOYSA-N |
Smiles | OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.85 | 100 | |
ethanol | 7.97 | 20 |
Thefollowingdataisbasedontheproductmolecularweight398.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.51mL | 12.55mL | 25.1mL |
5mM | 0.5mL | 2.51mL | 5.02mL |
10mM | 0.25mL | 1.25mL | 2.51mL |
50mM | 0.05mL | 0.25mL | 0.5mL |