HighaffinityMycinhibitor(Kd=6.5nM).DisruptsMyc-Maxinteraction.InhibitsMyc-dependentcancercelllineproliferationinvitro.InhibitsgrowthofMDA-MB-231breastcancercellxenograftsinmice.Brainpenetrant.
M.Wt | 385.37 |
Formula | C22H15N3O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 581073-80-5 |
PubChemID | 85855478 |
InChIKey | GTTDVYCKFQYVNN-UHFFFAOYSA-N |
Smiles | O=C(N)C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.54 | 100 |
Thefollowingdataisbasedontheproductmolecularweight385.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.59mL | 12.97mL | 25.95mL |
5mM | 0.52mL | 2.59mL | 5.19mL |
10mM | 0.26mL | 1.3mL | 2.59mL |
50mM | 0.05mL | 0.26mL | 0.52mL |