Selectiveinducerofneuronaldifferentiation;inducesneuronaldifferentiationinculturedhippocampalneuralprogenitorcells(NPCs)byinteractingwithTACC3(EC50~1μM).Suppressesastrocyteformation.Alsoinducesaccelerationofneuronaldifferentiationinthehippocampaldentategyrusinvivo.
KHS101hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 375.92 |
Formula | C18H21N5S.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
PubChemID | 90488983 |
InChIKey | INVQHPQJFRKGIO-UHFFFAOYSA-N |
Smiles | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 18.8 | 50 | |
ethanol | 18.8 | 50 |
Thefollowingdataisbasedontheproductmolecularweight375.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.66mL | 13.3mL | 26.6mL |
5mM | 0.53mL | 2.66mL | 5.32mL |
10mM | 0.27mL | 1.33mL | 2.66mL |
50mM | 0.05mL | 0.27mL | 0.53mL |