Selectivesolubleadenylylcyclase(sAC)inhibitor(IC50=3-10μMinvivo).Inerttowardstransmembraneadenylylcyclase(tmAC)invitroandinwholecellsatconcentrationsupto300μM.BlockssynthesisofcAMPanddisplaysanantiapoptoticeffectatconcentrationsof1-100μM.
| M.Wt | 419.3 |
| Formula | C17H15BrN4O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 330676-02-3 |
| PubChemID | 6843191 |
| InChIKey | GEHVZUUHMWNMAY-UHFFFAOYSA-N |
| Smiles | OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.93 | 100 | |
| ethanol | 10.48 | 25 |
Thefollowingdataisbasedontheproductmolecularweight419.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.38mL | 11.92mL | 23.85mL |
| 5mM | 0.48mL | 2.38mL | 4.77mL |
| 10mM | 0.24mL | 1.19mL | 2.38mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |



