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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/KC7F2/4324/50/50 mg
产品编号:4324/50
市  场 价:¥7500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$375.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/KC7F2/4324/50/50 mg
商品介绍
Description:HIF-1αinhibitor;down-regulatesHIF-1αproteinsynthesis
ChemicalName:N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHIF-1α.Thoughttoactviadown-regulationofHIF-1αproteinsynthesis;reducesphosphorylationofeIF4Ebindingprotein1(4EBP1)andp70S6Kinhypoxicconditions.Alsoblockshypoxia-inducedHIF-1αaccumulationinarangeofhumancancercelllines.InhibitstheexpressionofHIFtargetgenes,suchascarbonicanhydraseIXandMMP2.

TechnicalData

M.Wt570.38
FormulaC16H16Cl4N2O4S4
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber927822-86-4
PubChemID16047442
InChIKeyREQLACDIZMLXIC-UHFFFAOYSA-N
SmilesClC1=CC=C(Cl)C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO57.04100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight570.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.75mL8.77mL17.53mL
5mM0.35mL1.75mL3.51mL
10mM0.18mL0.88mL1.75mL
50mM0.04mL0.18mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet