请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Jervine/4717/10/10 mg
产品编号:4717/10
市  场 价:¥4500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Jervine/4717/10/10 mg
商品介绍
Description:InhibitorofHedgehog(Hh)signaling;bindsdirectlytoSmo
ChemicalName:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHedgehogsignaling(IC50=500-700nM);bindsdirectlytoSmoothened(Smo).InhibitstheresponseoftargettissuestoSonichedgehogsignaling,possIBLyviathesterolsensingdomainofPatched.Teratogenic.

TechnicalData

M.Wt425.6
FormulaC27H39NO3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber469-59-0
PubChemID10098
InChIKeyCLEXYFLHGFJONT-DNMILWOZSA-N
SmilesO[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO8.5120
ethanol21.2850

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight425.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.35mL11.75mL23.5mL
5mM0.47mL2.35mL4.7mL
10mM0.23mL1.17mL2.35mL
50mM0.05mL0.23mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet