Rapidlystabilizespre-formedactinfilamentsandinhibitstheirdisassemblyinvitro.AlsoinducespolymerizationofactinmonomersintoF-actininvivo.ShowntobindtoF-actincompetitivelywithphalloidin(Cat.No.4535)(Kd~15nM).Exhibitsantifungalandantiproliferativeeffects(IC50=35nMforantiproliferativeactivityinPC3cells).Cellpermeable.
M.Wt | 709.67 |
Formula | C36H45BrN4O6 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 102396-24-7 |
PubChemID | 9831636 |
InChIKey | GQWYWHOHRVVHAP-DHKPLNAMSA-N |
Smiles | C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2 | 3 |
Thefollowingdataisbasedontheproductmolecularweight709.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.41mL | 7.05mL | 14.09mL |
5mM | 0.28mL | 1.41mL | 2.82mL |
10mM | 0.14mL | 0.7mL | 1.41mL |
50mM | 0.03mL | 0.14mL | 0.28mL |