InhibitorofcanonicalWntsignaling(IC50=790nM).Targetstheβ-catenindestructioncomplex(GSK-3beta/AXIN/APC).IncreasesAXIN2anddecreasesactiveβ-cateninlevelsincolorectalcancer(CRC)cells.AlsoarrestscellcycleinG1andinhibitsproliferationofCRCcellsinvitro.Inhibitstumorgrowthandformationinmousemodels.
JW74isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 456.52 |
Formula | C24H20N6O2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 863405-60-1 |
PubChemID | 16013152 |
InChIKey | KRIKILRRJCIWNB-UHFFFAOYSA-N |
Smiles | COC1=CC=C(N2C(SCC3=NC(C4=CC=C(C)C=C4)=NO3)=NN=C2C5=CC=NC=C5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.65 | 100 |
Thefollowingdataisbasedontheproductmolecularweight456.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.19mL | 10.95mL | 21.9mL |
5mM | 0.44mL | 2.19mL | 4.38mL |
10mM | 0.22mL | 1.1mL | 2.19mL |
50mM | 0.04mL | 0.22mL | 0.44mL |