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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/JW 74/5653/50/50 mg
产品编号:5653/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/JW 74/5653/50/50 mg
商品介绍
Description:Wntpathwayinhibitor
ChemicalName:4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxADIazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofcanonicalWntsignaling(IC50=790nM).Targetstheβ-catenindestructioncomplex(GSK-3beta/AXIN/APC).IncreasesAXIN2anddecreasesactiveβ-cateninlevelsincolorectalcancer(CRC)cells.AlsoarrestscellcycleinG1andinhibitsproliferationofCRCcellsinvitro.Inhibitstumorgrowthandformationinmousemodels.

CompoundLibraries

JW74isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt456.52
FormulaC24H20N6O2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber863405-60-1
PubChemID16013152
InChIKeyKRIKILRRJCIWNB-UHFFFAOYSA-N
SmilesCOC1=CC=C(N2C(SCC3=NC(C4=CC=C(C)C=C4)=NO3)=NN=C2C5=CC=NC=C5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.65100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight456.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.19mL10.95mL21.9mL
5mM0.44mL2.19mL4.38mL
10mM0.22mL1.1mL2.19mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet