Sphingosine-1-phosphate(S1P)receptorantagonist,highlyselectiveforS1P2(EDG-5).InhibitsS1PbindingtohumanS1P2receptorswithanIC50valueof17.6nM.Atconcentrationsupto10μM,displays4.2%inhibitionofS1P3anddoesnotantagonizeS1P1.EnhancesS1P-inducedangiogenesisinvivo.
JTE013isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 408.29 |
Formula | C17H19N7OCl2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 547756-93-4 |
PubChemID | 10223146 |
InChIKey | RNSLRQNDXRSASX-UHFFFAOYSA-N |
Smiles | CC(C)C1=C2C(C)=NN(C)C2=NC(NNC(=O)NC2=CC(Cl)=NC(Cl)=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
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Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 40.83 | 100 | |
ethanol | 40.83 | 100 |
Thefollowingdataisbasedontheproductmolecularweight408.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.45mL | 12.25mL | 24.49mL |
5mM | 0.49mL | 2.45mL | 4.9mL |
10mM | 0.24mL | 1.22mL | 2.45mL |
50mM | 0.05mL | 0.24mL | 0.49mL |