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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/JTE 013/2392/10/10 mg
产品编号:2392/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/JTE 013/2392/10/10 mg
商品介绍
Description:S1P2receptorantagoNIST
ChemicalName:1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Sphingosine-1-phosphate(S1P)receptorantagonist,highlyselectiveforS1P2(EDG-5).InhibitsS1PbindingtohumanS1P2receptorswithanIC50valueof17.6nM.Atconcentrationsupto10μM,displays4.2%inhibitionofS1P3anddoesnotantagonizeS1P1.EnhancesS1P-inducedangiogenesisinvivo.

CompoundLibraries

JTE013isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt408.29
FormulaC17H19N7OCl2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber547756-93-4
PubChemID10223146
InChIKeyRNSLRQNDXRSASX-UHFFFAOYSA-N
SmilesCC(C)C1=C2C(C)=NN(C)C2=NC(NNC(=O)NC2=CC(Cl)=NC(Cl)=C2)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.83100
ethanol40.83100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight408.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.45mL12.25mL24.49mL
5mM0.49mL2.45mL4.9mL
10mM0.24mL1.22mL2.45mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet