Microtubuledestabilizerthatblockstubulinpolymerization(IC50=0.3μM).Blockscellcycleprogressionatmetaphaseanddisplaysantitumoractivityagainstavarietyofmalignanciesinvitro(IC50valuesrangingfrom0.036-0.285μM).InducescompletetumorremissionintheYoshidaAH13ratsarcomamodelinvivo.Lacksneurotoxicityduetoanabilitytodiscriminatebetweenposttranslationallymodifiedtubulininmatureneuronalmicrotubulesandless-modifiedtubulinpresentinimmatureneuronalornonneuronalmicrotubules.DisplaysoralavailabilityandefficacytowardsMDRtumorcells.
M.Wt | 389.83 |
Formula | C22H16ClN3O2 |
Storage | Desiccateat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 204205-90-3 |
PubChemID | 2929 |
InChIKey | SOLIIYNRSAWTSQ-UHFFFAOYSA-N |
Smiles | ClC(C=C3)=CC=C3CN2C1=CC=CC=C1C(C(C(NC4=CC=NC=C4)=O)=O)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.75 | 25 |
Thefollowingdataisbasedontheproductmolecularweight389.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.57mL | 12.83mL | 25.65mL |
5mM | 0.51mL | 2.57mL | 5.13mL |
10mM | 0.26mL | 1.28mL | 2.57mL |
50mM | 0.05mL | 0.26mL | 0.51mL |