InhibitorofWntsignaling.InducesanincreaseinAxin2proteinlevels;promotesβ-cateninphosphorylationbystabilizingAxin-scaffoldeddestructioncomplexes.Negativecontrolexo-IWR(Cat.No.3947)available.
endo-IWR1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 409.44 |
| Formula | C25H19N3O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1127442-82-3 |
| PubChemID | 90488854 |
| InChIKey | MFEADGGBEDIZRE-MGIYQXMMSA-N |
| Smiles | [H][C@]13[C@](C(N(C4=CC=C(C(NC5=CC=CC6=C5N=CC=C6)=O)C=C4)C3=O)=O)([H])[C@H]2C=C[C@@H]1C2.[H][C@@]79[C@@](C(N(C%10=CC=C(C(NC%11=CC=CC%12=C%11N=CC=C%12)=O)C=C%10)C9=O)=O)([H])[C@@H]8C=C[C@H]7C8 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight409.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.21mL | 24.42mL |
| 5mM | 0.49mL | 2.44mL | 4.88mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |



