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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ITH 12575/5692/10/10 mg
产品编号:5692/10
市  场 价:¥3780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ITH 12575/5692/10/10 mg
商品介绍
Description:MitochondrialNa+/Ca2+exchange(mNCX)inhibitor.
ChemicalName:7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MitochondrialNa+/Ca2+exchange(mNCX)inhibitor.ReducesCa2+effluxfromthemitochondriatothecytosolinHeLacells(EC50=0.69μM).Protectsagainstglutamate-inducedexcitotoxitiyinrathippocampalslicesandoligomycinA/rotenoneinducedoxidativestressinneuroblastomacellsinvitro.

TechnicalData

M.Wt331.86
FormulaC18H18ClNOS
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber1802013-08-6
PubChemID124201848
InChIKeyRDMUJSJZBYAAEF-UHFFFAOYSA-N
SmilesO=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO33.19100
ethanol6.6420

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight331.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.01mL15.07mL30.13mL
5mM0.6mL3.01mL6.03mL
10mM0.3mL1.51mL3.01mL
50mM0.06mL0.3mL0.6mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet