MitochondrialNa+/Ca2+exchange(mNCX)inhibitor.ReducesCa2+effluxfromthemitochondriatothecytosolinHeLacells(EC50=0.69μM).Protectsagainstglutamate-inducedexcitotoxitiyinrathippocampalslicesandoligomycinA/rotenoneinducedoxidativestressinneuroblastomacellsinvitro.
M.Wt | 331.86 |
Formula | C18H18ClNOS |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1802013-08-6 |
PubChemID | 124201848 |
InChIKey | RDMUJSJZBYAAEF-UHFFFAOYSA-N |
Smiles | O=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 33.19 | 100 | |
ethanol | 6.64 | 20 |
Thefollowingdataisbasedontheproductmolecularweight331.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.01mL | 15.07mL | 30.13mL |
5mM | 0.6mL | 3.01mL | 6.03mL |
10mM | 0.3mL | 1.51mL | 3.01mL |
50mM | 0.06mL | 0.3mL | 0.6mL |