Endogenousarylhydrocarbonreceptor(AhR)agonist(Ki=3nM).DecreasesOct4levelsinU87glioblastomacells.Inducesstem-likecancercelldifferentiationinU87tumorspheresandinhibitsovariancancercellproliferationinvitro.SuppressestumorgrowthinU87andOVCAR-3cellxenograftsinmice.AlsoinhibitsTGF-β-inducedhumanmyofibroblastdifferentiation.
Soldunderlicense,USPatentApplication2002183524
ITEisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 286.3 |
Formula | C14H10N2O3S |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 448906-42-1 |
PubChemID | 4668801 |
InChIKey | KDDXOGDIPZSCTM-UHFFFAOYSA-N |
Smiles | COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.63 | 100 |
Thefollowingdataisbasedontheproductmolecularweight286.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.49mL | 17.46mL | 34.93mL |
5mM | 0.7mL | 3.49mL | 6.99mL |
10mM | 0.35mL | 1.75mL | 3.49mL |
50mM | 0.07mL | 0.35mL | 0.7mL |