Neurogenicagent.MediatesneuroDreportergeneinductionviaactivationofCa2+influx;increasesexpressionofneurogenicdifferentiation1(NeuroD1)transcriptionfactor.Inducesneuronaldifferentiationinhumancorticalneuronalcells(HCN),adultmousewholebrain(MWB)andsubventricularzone(SVZ)progenitors.AlsoshowntoinducecardiomyogenicdifferentiationofNotch-activatedepicardium-derivedcellsinvitro.
ISX9isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 234.27 |
Formula | C11H10N2O2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 832115-62-5 |
PubChemID | 19582717 |
InChIKey | SYENTKHGMVKGAQ-UHFFFAOYSA-N |
Smiles | O=C(NC2CC2)C1=NOC(C3=CC=CS3)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.43 | 100 | |
ethanol | 11.71 | 50 |
Thefollowingdataisbasedontheproductmolecularweight234.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.27mL | 21.34mL | 42.69mL |
5mM | 0.85mL | 4.27mL | 8.54mL |
10mM | 0.43mL | 2.13mL | 4.27mL |
50mM | 0.09mL | 0.43mL | 0.85mL |