Maintainsembryonicstemcell(ESC)pluripotencyinWnt3a-treatedcells;enablesWnt/β-catenin-drivenexpansionofmouseESCsandpreventsspontaneousdifferentiation.UpregulatesexpressionofOct4andSox2transcriptionfactors.Bindstoserine/threoninephosphatasePP2AandpreventsPP2A/Nkdinteraction.
IQ1isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 362.42 |
Formula | C21H22N4O2 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 331001-62-8 |
PubChemID | 56801 |
InChIKey | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
Smiles | CC(C(C=C3)=CC=C3/N=N/C(C(N)=O)=C2C1=CC=CC=C1CC(C)(C)N2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.24 | 100 | |
ethanol | 7.25 | 20 |
Thefollowingdataisbasedontheproductmolecularweight362.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.76mL | 13.8mL | 27.59mL |
5mM | 0.55mL | 2.76mL | 5.52mL |
10mM | 0.28mL | 1.38mL | 2.76mL |
50mM | 0.06mL | 0.28mL | 0.55mL |