PotentinhibitorofHIF-1αprolylhydroxylase-2(PHD2)(IC50=21nM).Displaysover100-foldselectivityforPHD2overfactorinhibitingHIF-1(FIH-1)andhistonedemethylasesJMJD2A,JMJD2C,JMJD2EandJMJD3.Cellpermeable.
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX2probesummaryontheSGCwebsite.
IOX2isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 352.34 |
Formula | C19H16N2O5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 931398-72-0 |
PubChemID | 54685215 |
InChIKey | CAOSCCRYLYQBES-UHFFFAOYSA-N |
Smiles | OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.23 | 100 |
Thefollowingdataisbasedontheproductmolecularweight352.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.84mL | 14.19mL | 28.38mL |
5mM | 0.57mL | 2.84mL | 5.68mL |
10mM | 0.28mL | 1.42mL | 2.84mL |
50mM | 0.06mL | 0.28mL | 0.57mL |