HistonedemethylaseJMJDinhibitor(IC50valuesare0.12,0.17,0.2,0.3,0.6and1μMforJMJD3,JMJD1A,JMJD2A,JMJD2E,JMJD2CandUTXrespectively).Cellpermeable;inhibitsJMJD2A-mediatedH3K9me3demethylationinHeLacells.
ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX1summaryontheSGCwebsite.
IOX1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight189.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.