HistonedemethylaseJMJDinhibitor(IC50valuesare0.12,0.17,0.2,0.3,0.6and1μMforJMJD3,JMJD1A,JMJD2A,JMJD2E,JMJD2CandUTXrespectively).Cellpermeable;inhibitsJMJD2A-mediatedH3K9me3demethylationinHeLacells.
ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX1summaryontheSGCwebsite.
IOX1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 189.17 |
Formula | C10H7NO3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 5852-78-8 |
PubChemID | 459617 |
InChIKey | JGRPKOGHYBAVMW-UHFFFAOYSA-N |
Smiles | OC2=CC=C(C(O)=O)C1=CC=CN=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 18.92 | 100 | |
DMSO | 18.92 | 100 |
Thefollowingdataisbasedontheproductmolecularweight189.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.29mL | 26.43mL | 52.86mL |
5mM | 1.06mL | 5.29mL | 10.57mL |
10mM | 0.53mL | 2.64mL | 5.29mL |
50mM | 0.11mL | 0.53mL | 1.06mL |