Hec1inhibitor.BindsHec1,inhibitingitsassociationwithNek2andkinetochores.Causesarrestofmitosisandinhibitsproliferationinbreastcancercelllines(GI50=10-20μM).
| M.Wt | 344.86 |
| Formula | C18H16N2OS.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 313553-47-8 |
| PubChemID | 71307591 |
| InChIKey | DYJVVODHGPIUPM-UHFFFAOYSA-N |
| Smiles | CC(C=C(C)C=C2)=C2C1=CSC(NC(C3=CC=CC=C3)=O)=N1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.84 | 100 | |
| ethanol | 3.08 | 10 |
Thefollowingdataisbasedontheproductmolecularweight344.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.9mL | 14.5mL | 29mL |
| 5mM | 0.58mL | 2.9mL | 5.8mL |
| 10mM | 0.29mL | 1.45mL | 2.9mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |



