InhibitorofinteractionbetweencalcineurinanditssubstratenuclearfactorofactivatedTcells(NFAT);blocksatthesubstraterecognitionsitebutnotatthecatalyticsite(Kd=0.8mM).InhibitsNFATdephosphorylationandnuclearimport.AlsopreventsinductionofcytokinemRNAsthataredownstreamtargetsofNFAT.
INCA-6isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 284.31 |
Formula | C20H12O2 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 3519-82-2 |
PubChemID | 230748 |
InChIKey | GCHPUOHXXCNSQL-UHFFFAOYSA-N |
Smiles | O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 5.69 | 20 |
Thefollowingdataisbasedontheproductmolecularweight284.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.52mL | 17.59mL | 35.17mL |
5mM | 0.7mL | 3.52mL | 7.03mL |
10mM | 0.35mL | 1.76mL | 3.52mL |
50mM | 0.07mL | 0.35mL | 0.7mL |