PotentSmoantagonist(IC50=7.6nM).SelectivelyinhibitsHedgehogsignalingoverWntandNotchsignalingpathways.BlocksSmoaccumulationinprimaryciliuminvitro.FluorescentanalogIHR-Cy3alsoavailable.
M.Wt | 454.13 |
Formula | C20H12Cl4N2O2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 548779-60-8 |
PubChemID | 2167042 |
InChIKey | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
Smiles | ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.08 | 20mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight454.13.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.2mL | 11.01mL | 22.02mL |
5mM | 0.44mL | 2.2mL | 4.4mL |
10mM | 0.22mL | 1.1mL | 2.2mL |
50mM | 0.04mL | 0.22mL | 0.44mL |