Cell-permeableinducerofdefinitiveendodermformationinmouseandhumanembryonicstemcells(ESCs)(EC50=223nMforinductionofSox17expressioninESCs).ReportedtoactivateTGF-βsignalinganddownstreamSmad2phosphorylation;upregulatesNodalexpression.PromotespancreaticProgenitorcellformationinvitro,andguttubeformationinvivo.
SoldforresearchpurposeunderlicensefromHarvardUniversity.
M.Wt | 240.3 |
Formula | C12H20N2O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1136466-93-7 |
PubChemID | 23836158 |
InChIKey | CVYPYYPTFNVREL-UHFFFAOYSA-N |
Smiles | O=C(N/N=C1/CCCC1)CCCCCC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.03 | 100 | |
water | 4.81 | 20 |
Thefollowingdataisbasedontheproductmolecularweight240.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.16mL | 20.81mL | 41.61mL |
5mM | 0.83mL | 4.16mL | 8.32mL |
10mM | 0.42mL | 2.08mL | 4.16mL |
50mM | 0.08mL | 0.42mL | 0.83mL |