Inducesdefinitiveendodermformationinmouseandhumanembryonicstemcells(ESCs)(EC50=125nM).ThoughttoactivatetheTGF-βsignalingpathway;inducesSmad2phosphorylationandincreaseslevelsofNodalexpression.
SoldforresearchpurposeunderlicensefromHarvardUniversity.
IDE1isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 306.31 |
| Formula | C15H18N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1160927-48-9 |
| PubChemID | 66974738 |
| InChIKey | ABKJCDILEUEJSH-UHFFFAOYSA-N |
| Smiles | OC(=O)CCCCCC(=O)NN=CC1=CC=CC=C1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.NaOH | 30.63 | 100 | |
| DMSO | 30.63 | 100 | |
| ethanol | 7.66 | 25 |
Thefollowingdataisbasedontheproductmolecularweight306.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.26mL | 16.32mL | 32.65mL |
| 5mM | 0.65mL | 3.26mL | 6.53mL |
| 10mM | 0.33mL | 1.63mL | 3.26mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |



