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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ICG 001/4505/10/10 mg
产品编号:4505/10
市  场 价:¥4500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ICG 001/4505/10/10 mg
商品介绍
Description:InhibitsTCF/β-catenin-mediatedtranscription
ChemicalName:(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofTCF/β-catenin-mediatedtranscription.Selectivelyinhibitsβ-catenin/CBPinteraction;displaysnoeffectonβ-catenin/p300interaction.Exhibitsgrowthinhibitoryeffectsincoloncarcinomacelllines(SW480andHCT-116cells);alsodisplaysefficacyinMinmouseandnudemouseSW620xenograftmodels.

TechnicalData

M.Wt548.63
FormulaC33H32N4O4
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber847591-62-2
PubChemID11238147
InChIKeyHQWTUOLCGKIECB-XZWHSSHBSA-N
SmilesO=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO54.86100
ethanol27.4350

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight548.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.82mL9.11mL18.23mL
5mM0.36mL1.82mL3.65mL
10mM0.18mL0.91mL1.82mL
50mM0.04mL0.18mL0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet