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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/20(S)-Hydroxycholesterol/4474/10/10 mg
产品编号:4474/10
市  场 价:¥3300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/20(S)-Hydroxycholesterol/4474/10/10 mg
商品介绍
Description:AllostericactivatorofHedgehog(Hh)signaling;inducesSmoaccumulation
ChemicalName:(3β)-Cholest-5-ene-3,20-diol
Purity:≥95%
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AllostericactivatoroftheHedgehogsignalingpathwaySmoothened(Smo)oncoprotein;bindsatasitedistinctfromthecanonicalcyclopaminebindingsite.ActivatesHedgehog(Hh)signaling(EC50~3μMforinductionofHhreportergenetranscriptionininNIH3T3cells).InducesSmoaccumulationinprimarycilia;alsoexhibitsosteogenicactivityandactivatestheliverXreceptor(LXR).

TechnicalData

M.Wt402.65
FormulaC27H46O2
StorageStoreat-20°C
Purity≥95%
CASNumber516-72-3
PubChemID440711
InChIKeyMCKLJFJEQRYRQT-MGNSQDQZSA-N
SmilesO[C@H](C4)CC[C@@]1(C)C4=CC[C@]2([H])[C@@]([H])1CC[C@@]3(C)[C@]([H])2CC[C@@]([H])3[C@](C)(O)CCCC(C)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
ethanol40.26100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight402.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.48mL12.42mL24.84mL
5mM0.5mL2.48mL4.97mL
10mM0.25mL1.24mL2.48mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet