AllostericactivatoroftheHedgehogsignalingpathwaySmoothened(Smo)oncoprotein;bindsatasitedistinctfromthecanonicalcyclopaminebindingsite.ActivatesHedgehog(Hh)signaling(EC50~3μMforinductionofHhreportergenetranscriptionininNIH3T3cells).InducesSmoaccumulationinprimarycilia;alsoexhibitsosteogenicactivityandactivatestheliverXreceptor(LXR).
M.Wt | 402.65 |
Formula | C27H46O2 |
Storage | Storeat-20°C |
Purity | ≥95% |
CASNumber | 516-72-3 |
PubChemID | 440711 |
InChIKey | MCKLJFJEQRYRQT-MGNSQDQZSA-N |
Smiles | O[C@H](C4)CC[C@@]1(C)C4=CC[C@]2([H])[C@@]([H])1CC[C@@]3(C)[C@]([H])2CC[C@@]([H])3[C@](C)(O)CCCC(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
ethanol | 40.26 | 100 |
Thefollowingdataisbasedontheproductmolecularweight402.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.48mL | 12.42mL | 24.84mL |
5mM | 0.5mL | 2.48mL | 4.97mL |
10mM | 0.25mL | 1.24mL | 2.48mL |
50mM | 0.05mL | 0.25mL | 0.5mL |