AllostericinhibitorofRAD52;inhibitsRAD52bindingtosinglestrandDNAbindingdomains(IC50=1.1μM).SelectivelyinhibitsproliferationofBRCA-deficientcancercellsinvitro.AlsoinhibitsAPE1.
M.Wt | 213.19 |
Formula | C9H11NO5 |
Storage | Storeat-20°C |
CASNumber | 21373-30-8 |
PubChemID | 107794 |
InChIKey | YLKRUSPZOTYMAT-UHFFFAOYSA-N |
Smiles | OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1MHCl | 21.32 | 100 |
Thefollowingdataisbasedontheproductmolecularweight213.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.69mL | 23.45mL | 46.91mL |
5mM | 0.94mL | 4.69mL | 9.38mL |
10mM | 0.47mL | 2.35mL | 4.69mL |
50mM | 0.09mL | 0.47mL | 0.94mL |