HECTE3ubiquitinligaseinhibitor;inhibitsNedd4,Smurf2andWWP1(IC50valuesare6.3,6.8and6.9μMrespectively).SelectiveforHECT-mediatedoverRING-mediatedubiquitination.
HeclinisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 283.32 |
| Formula | C17H17NO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 890605-54-6 |
| PubChemID | 7464118 |
| InChIKey | SPTWXRJNCFIDRQ-ZHACJKMWSA-N |
| Smiles | CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.33 | 100 | |
| ethanol | 14.17 | 50 |
Thefollowingdataisbasedontheproductmolecularweight283.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.53mL | 17.65mL | 35.3mL |
| 5mM | 0.71mL | 3.53mL | 7.06mL |
| 10mM | 0.35mL | 1.76mL | 3.53mL |
| 50mM | 0.07mL | 0.35mL | 0.71mL |



