Proposedastheendogenousligandforimidazolinebindingsites.BindstoI1-sitesinratkidney(IC50=31nM)andI2-sites(Ki=49nM).Producesdose-dependenthypotensioninvivothatisreversedbyefaroxan(Cat.No.0792).PotentinhibitorofmonoamineoxidaseAandB(IC50valuesare0.5and5μMrespectively).
M.Wt | 182.22 |
Formula | C12H10N2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 486-84-0 |
PubChemID | 5281404 |
InChIKey | PSFDQSOCUJVVGF-UHFFFAOYSA-N |
Smiles | CC1=NC=CC2=C1NC1=C2C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 1.82 | 10 | |
DMSO | 21.87 | 100 | |
ethanol | 21.87 | 100 |
Thefollowingdataisbasedontheproductmolecularweight182.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.49mL | 27.44mL | 54.88mL |
5mM | 1.1mL | 5.49mL | 10.98mL |
10mM | 0.55mL | 2.74mL | 5.49mL |
50mM | 0.11mL | 0.55mL | 1.1mL |