请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/HPI 1/3839/50/50 mg
产品编号:3839/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/HPI 1/3839/50/50 mg
商品介绍
Description:InhibitsHedgehogsignaling
ChemicalName:1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylicacid2-methoxyethylester
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Hedgehog(Hh)signalinginhibitor.InhibitsSonichedgehog(Shh)-,SAG-andGli-inducedHhpathwayactivationinShh-LIGHT2cells(IC50valuesare1.5,1.5,4and6μMforShh-,SAG-,Gli2-andGli1-inducedactivation).AlsoinhibitsHhpathwayactivationinSmoM2-LIGHTcells(IC50=2.5μM);inhibitstheproliferationofcerebellargranuleneuronprecursorsexpressingSmoM2.DoesnotinhibitWntsignaling.

TechnicalData

M.Wt463.52
FormulaC27H29NO6
StorageStoreat-20°C
Purity≥95%(HPLC)
CASNumber599150-20-6
PubChemID2926768
InChIKeyZXSWZQSYZYMZKS-UHFFFAOYSA-N
SmilesCC2=C(C(OCCOC)=O)C(C3=CC(O)=CC=C3)C1=C(N2)CC(C4=C(OC)C=CC=C4)CC1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.35100
ethanol46.35100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight463.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.16mL10.79mL21.57mL
5mM0.43mL2.16mL4.31mL
10mM0.22mL1.08mL2.16mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet