Hedgehog(Hh)signalinginhibitor.InhibitsSonichedgehog(Shh)-,SAG-andGli-inducedHhpathwayactivationinShh-LIGHT2cells(IC50valuesare1.5,1.5,4and6μMforShh-,SAG-,Gli2-andGli1-inducedactivation).AlsoinhibitsHhpathwayactivationinSmoM2-LIGHTcells(IC50=2.5μM);inhibitstheproliferationofcerebellargranuleneuronprecursorsexpressingSmoM2.DoesnotinhibitWntsignaling.
M.Wt | 463.52 |
Formula | C27H29NO6 |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 599150-20-6 |
PubChemID | 2926768 |
InChIKey | ZXSWZQSYZYMZKS-UHFFFAOYSA-N |
Smiles | CC2=C(C(OCCOC)=O)C(C3=CC(O)=CC=C3)C1=C(N2)CC(C4=C(OC)C=CC=C4)CC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.35 | 100 | |
ethanol | 46.35 | 100 |
Thefollowingdataisbasedontheproductmolecularweight463.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.16mL | 10.79mL | 21.57mL |
5mM | 0.43mL | 2.16mL | 4.31mL |
10mM | 0.22mL | 1.08mL | 2.16mL |
50mM | 0.04mL | 0.22mL | 0.43mL |