InhibitorofHdm2ubiquitinligase(E3).BlocksHdm2-mediatedubiquitylationandproteasomaldegradationofp53;activatesp53-dependenttranscription.Inducesapoptosisinseveraltumorcelllinesthatexpresswild-typep53suchasLOX-IMVI,A549,HT1080andU2OS.
| M.Wt | 414.33 |
| Formula | C18H23N5O2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 502137-98-6 |
| PubChemID | 72193867 |
| InChIKey | WUEMKAQTAIRDOA-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.78 | 10 | |
| water | 37.79 | 100 |
Thefollowingdataisbasedontheproductmolecularweight414.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.07mL | 24.14mL |
| 5mM | 0.48mL | 2.41mL | 4.83mL |
| 10mM | 0.24mL | 1.21mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |



