Broadspectrumsteroidreceptorligand;mineralocorticoid,progesteroneandglucocorticoidreceptorantagoNIST(Kivaluesare37,224and252nMrespectively)andweakandrogenreceptoragonist(Ki=315nM).InducesapoptosisinprostatecancercellsandinhibitsangiogenesisviasuppressionoftheVEGF-VEGFR2-Aktsignalingpathway.ExhibitsantilipidemicactivityviaantagonismofthefarnesoidXreceptor(FXR)anddisplaysantiseptic,antirheumaticandanti-inflammatoryactivityinvivo.Moreactiveisomerofguggulsterone(Cat.No.2013).
M.Wt | 312.45 |
Formula | C21H28O2 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 39025-23-5 |
PubChemID | 6450278 |
InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
Smiles | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]/4(C)[C@]([H])3CC(C4=C/C)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 6.25 | 20mMwithgentlewarming | |
ethanol | 3.12 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.2mL | 16mL | 32.01mL |
5mM | 0.64mL | 3.2mL | 6.4mL |
10mM | 0.32mL | 1.6mL | 3.2mL |
50mM | 0.06mL | 0.32mL | 0.64mL |