Broadspectrumsteroidreceptorligand;bindswithhighaffinitytomineralocorticoidreceptors(Ki=39nM)andloweraffinitytoprogesterone,androgenandglucocorticoidreceptors(Kivaluesare201,240and224nMrespectively).FunctionsprimarilyasanantagoNISTofthesereceptors,withtheexceptionoftheprogesteronereceptorwhereitdisplayspartialagonisteffects.Alsoexertshypolipidemicactivity,likelyviaantagonismofthereceptorforbileacids(farnesoidXreceptor;FXR).
M.Wt | 312.45 |
Formula | C21H28O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 95975-55-6 |
PubChemID | 146898 |
InChIKey | WDXRGPWQVHZTQJ-NRJJLHBYSA-N |
Smiles | [H][C@@]12CC(=O)C(=CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
ethanol | 3.12 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.2mL | 16mL | 32.01mL |
5mM | 0.64mL | 3.2mL | 6.4mL |
10mM | 0.32mL | 1.6mL | 3.2mL |
50mM | 0.06mL | 0.32mL | 0.64mL |