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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Geldanamycin/1368/1/1 mg
产品编号:1368/1
市  场 价:¥6980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$349.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Geldanamycin/1368/1/1 mg
商品介绍
Description:SelectiveHsp90inhibitor
ChemicalName:9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azABIcyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivelyinhibitsheatshockprotein90(Hsp90).BindstotheATPsiteofHsp90(Kd=1.2μM)andinhibitsitschaperoneactivity.Consequentlyinhibitsactivitiesofoncogenickinases(e.g.src,Raf),p53andsteroidreceptors.Demonstratesantiproliferativeeffectonbreastcancerstem-likecells.

TechnicalData

M.Wt560.64
FormulaC29H40N2O9
StorageDesiccateat-20°C
Purity≥98%(HPLC)
CASNumber30562-34-6
PubChemID13017912
InChIKeyQTQAWLPCGQOSGP-PHLMVCJGSA-N
SmilesO=C1C(OC)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO5.6110

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight560.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.78mL8.92mL17.84mL
5mM0.36mL1.78mL3.57mL
10mM0.18mL0.89mL1.78mL
50mM0.04mL0.18mL0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet