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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Gedunin/3387/1/1 mg
产品编号:3387/1
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Gedunin/3387/1/1 mg
商品介绍
Description:Hsp90inhibitor;exhibitsanticancerandantimalarialactivity
ChemicalName:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

NaturallyoccurringHsp90inhibitor.InducesHsp90-dependentclientproteindegradationanddisplaysantiproliferativeactivityinvitro(IC50valuesare3.22,8.84and16.8μMinSKBr3,MCF-7andCaCo-2cancercelllinesrespectively).Decreasesovariancancercellproliferationinvitroandmayenhancecisplatin-inducedreductioninproliferation(CAT.No3387).AlsoexhibitsantimalarialactivityagainstP.falciparum(IC50valuesare0.14and3.1μMinparasitedevelopmentand[3H]-hypoxanthineuptakeassaysrespectively).

TechnicalData

M.Wt482.57
FormulaC28H34O7
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber2753-30-2
PubChemID12004512
InChIKeyYJXDGWUNRYLINJ-BHAPSIHVSA-N
SmilesO=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO48.26100
ethanol4.8310mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.07mL10.36mL20.72mL
5mM0.41mL2.07mL4.14mL
10mM0.21mL1.04mL2.07mL
50mM0.04mL0.21mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet