Description:Hsp90inhibitor;exhibitsanticancerandantimalarialactivity
ChemicalName:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
NaturallyoccurringHsp90inhibitor.InducesHsp90-dependentclientproteindegradationanddisplaysantiproliferativeactivityinvitro(IC50valuesare3.22,8.84and16.8μMinSKBr3,MCF-7andCaCo-2cancercelllinesrespectively).Decreasesovariancancercellproliferationinvitroandmayenhancecisplatin-inducedreductioninproliferation(CAT.No3387).AlsoexhibitsantimalarialactivityagainstP.falciparum(IC50valuesare0.14and3.1μMinparasitedevelopmentand[3H]-hypoxanthineuptakeassaysrespectively).
TechnicalData
M.Wt | 482.57 |
Formula | C28H34O7 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 2753-30-2 |
PubChemID | 12004512 |
InChIKey | YJXDGWUNRYLINJ-BHAPSIHVSA-N |
Smiles | O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
---|
Solubility |
---|
DMSO | 48.26 | 100 |
ethanol | 4.83 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight482.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|
1mM | 2.07mL | 10.36mL | 20.72mL |
5mM | 0.41mL | 2.07mL | 4.14mL |
10mM | 0.21mL | 1.04mL | 2.07mL |
50mM | 0.04mL | 0.21mL | 0.41mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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