Selectiveconnexin43(Cx43)hemichannelblocker;hasnoeffectongapjunctioncouplingorPanx-1channels.Reducesmitochondrialpotassiuminfluxincardiomyocytesandattenuatesglutamate-triggeredATPreleaseinprimaryastrocytes.Modestlyreducesinfarctsizeinamouseischemiamodel.
M.Wt | 1161.45 |
Formula | C55H96N14O13 |
Sequence | KQIEIKKFK |
Storage | Storeat-20°C |
CASNumber | 1507930-57-5 |
PubChemID | 91691126 |
InChIKey | IEAKEKFIXUZWEH-PKMKMBMKSA-N |
Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto2mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight1161.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.86mL | 4.3mL | 8.61mL |
5mM | 0.17mL | 0.86mL | 1.72mL |
10mM | 0.09mL | 0.43mL | 0.86mL |
50mM | 0.02mL | 0.09mL | 0.17mL |