Peptide,correspondingtoresidues63-75ofconnexin43,whichisagapjunctionblocker.Attenuatesrhythmiccontractileactivityofrabbitarterialsmoothmuscle(IC50=28.4μM).AlsoinhibitsIP3-inducedATPrelease,withoutinhibitinggapjunctionalcouplinginendothelialcells.
M.Wt | 1550.79 |
Formula | C70H107N19O19S |
Sequence | VCYDKSFPISHVR |
Storage | Desiccateat-20°C |
CASNumber | 197250-15-0 |
PubChemID | 25088334 |
InChIKey | FDPIMWZHGJNESB-VCSXYVMHSA-N |
Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto2mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight1550.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.64mL | 3.22mL | 6.45mL |
5mM | 0.13mL | 0.64mL | 1.29mL |
10mM | 0.06mL | 0.32mL | 0.64mL |
50mM | 0.01mL | 0.06mL | 0.13mL |