Peptide,correspondingtoresidues63-75ofconnexin43,whichisagapjunctionblocker.Attenuatesrhythmiccontractileactivityofrabbitarterialsmoothmuscle(IC50=28.4μM).AlsoinhibitsIP3-inducedATPrelease,withoutinhibitinggapjunctionalcouplinginendothelialcells.
| M.Wt | 1550.79 |
| Formula | C70H107N19O19S |
| Sequence | VCYDKSFPISHVR |
| Storage | Desiccateat-20°C |
| CASNumber | 197250-15-0 |
| PubChemID | 25088334 |
| InChIKey | FDPIMWZHGJNESB-VCSXYVMHSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solubility | Solubleto2mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight1550.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.64mL | 3.22mL | 6.45mL |
| 5mM | 0.13mL | 0.64mL | 1.29mL |
| 10mM | 0.06mL | 0.32mL | 0.64mL |
| 50mM | 0.01mL | 0.06mL | 0.13mL |



