ApoptosisinducerinseveraltumorcelllinesincludingT47Dcells.Activatescaspases(EC50valuesare0.78-1.64μM)andcompetitivelyinhibitsantiapoptoticBcl-2familyproteins(IC50valuesare1.47,1.21,2.02,0.66,1.06and0.79μMforBcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1andMcl-1respectively).Reversesgefitinib-resistanceinmicebearingtumorswithEGFR-T790Mmutation.AlsoblocksKir2.1channels(EC50≤100nM).
M.Wt | 628.75 |
Formula | C38H44O8 |
Storage | Storeat-20°C |
CASNumber | 2752-65-0 |
PubChemID | 15559465 |
InChIKey | GEZHEQNLKAOMCA-MYCCNKBCSA-N |
Smiles | C/C(C)=C/CC[C@@](C=C2)(C)OC1=C2C(O)=C(C(C([C@]45O3)=C[C@H](C[C@@H]56)C([C@](OC(C)6C)4C/C=C(C(O)=O)/C)=O)=O)C3=C1C/C=C(C)/C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.16 | 75 | |
ethanol | 62.87 | 100 |
Thefollowingdataisbasedontheproductmolecularweight628.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.59mL | 7.95mL | 15.9mL |
5mM | 0.32mL | 1.59mL | 3.18mL |
10mM | 0.16mL | 0.8mL | 1.59mL |
50mM | 0.03mL | 0.16mL | 0.32mL |