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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Gambogic acid/3590/10/10 mg
产品编号:3590/10
市  场 价:¥2300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$115.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Gambogic acid/3590/10/10 mg
商品介绍
Description:Apoptosisinducer.ActivatescaspasesandinhibitsBcl-2familyproteins
ChemicalName:(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ApoptosisinducerinseveraltumorcelllinesincludingT47Dcells.Activatescaspases(EC50valuesare0.78-1.64μM)andcompetitivelyinhibitsantiapoptoticBcl-2familyproteins(IC50valuesare1.47,1.21,2.02,0.66,1.06and0.79μMforBcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1andMcl-1respectively).Reversesgefitinib-resistanceinmicebearingtumorswithEGFR-T790Mmutation.AlsoblocksKir2.1channels(EC50≤100nM).

TechnicalData

M.Wt628.75
FormulaC38H44O8
StorageStoreat-20°C
CASNumber2752-65-0
PubChemID15559465
InChIKeyGEZHEQNLKAOMCA-MYCCNKBCSA-N
SmilesC/C(C)=C/CC[C@@](C=C2)(C)OC1=C2C(O)=C(C(C([C@]45O3)=C[C@H](C[C@@H]56)C([C@](OC(C)6C)4C/C=C(C(O)=O)/C)=O)=O)C3=C1C/C=C(C)/C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.1675
ethanol62.87100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight628.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.59mL7.95mL15.9mL
5mM0.32mL1.59mL3.18mL
10mM0.16mL0.8mL1.59mL
50mM0.03mL0.16mL0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet