CYP17inhibitor(IC50=300nM)andandrogenreceptorantagonist(IC50=384nMinPC3-ARcells).InhibitsDHT-stimulatedprostatecancercellproliferationinvitro.ExhibitsantitumoractivityinSCIDmicebearingprostatecancerxenografts.
| M.Wt | 388.55 |
| Formula | C26H32N2O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 851983-85-2 |
| PubChemID | 11188409 |
| InChIKey | PAFKTGFSEFKSQG-PAASFTFBSA-N |
| Smiles | [H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@H](CC[C@]34C)O)[H])[H])C)N5C=NC6=CC=CC=C56 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.43 | 50 | |
| ethanol | 19.43 | 50 |
Thefollowingdataisbasedontheproductmolecularweight388.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.87mL | 25.74mL |
| 5mM | 0.51mL | 2.57mL | 5.15mL |
| 10mM | 0.26mL | 1.29mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |



