CYP17inhibitor(IC50=300nM)andandrogenreceptorantagonist(IC50=384nMinPC3-ARcells).InhibitsDHT-stimulatedprostatecancercellproliferationinvitro.ExhibitsantitumoractivityinSCIDmicebearingprostatecancerxenografts.
M.Wt | 388.55 |
Formula | C26H32N2O |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 851983-85-2 |
PubChemID | 11188409 |
InChIKey | PAFKTGFSEFKSQG-PAASFTFBSA-N |
Smiles | [H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@H](CC[C@]34C)O)[H])[H])C)N5C=NC6=CC=CC=C56 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.43 | 50 | |
ethanol | 19.43 | 50 |
Thefollowingdataisbasedontheproductmolecularweight388.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.57mL | 12.87mL | 25.74mL |
5mM | 0.51mL | 2.57mL | 5.15mL |
10mM | 0.26mL | 1.29mL | 2.57mL |
50mM | 0.05mL | 0.26mL | 0.51mL |