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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GaTx2/4911/100U/100 ug
产品编号:4911/100U
市  场 价:¥6380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$319.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GaTx2/4911/100U/100 ug
商品介绍
Description:Highaffinity,selectiveClC-2blocker;inhibitsslow-gating
AlternativeNames:LeiuropeptideII
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

VeryhighaffinityClC-2blocker(apparentKD~50pM).SlowsClC-2activationandinhibitsslow-gatingbutdoesnotinhibitopenClC-2channels.SelectiveforClC-2overotherClCfamilymembers(ClC-0,ClC-1,ClC-3andClC-4),CFTR,GABAC,CaCCandKV1.2.

TechnicalData

M.Wt3192.54
FormulaC125H199N39O47S6
SequenceVSCEDCPDHCSTQKARAKCDNDKCVCEPI

(Modifications:Disulfidebridge:3-19,6-24,10-26)

StorageStoreat-20°C
CASNumber194665-85-5
PubChemID90488986
InChIKeyNDCNPIYRYDSDEM-TZZHORBYSA-N
Smiles[H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight3192.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.31mL1.57mL3.13mL
5mM0.06mL0.31mL0.63mL
10mM0.03mL0.16mL0.31mL
50mM0.01mL0.03mL0.06mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet