Potentβ3-adrenergicreceptorpartialagonist>1000-foldselectiveoverβ1-andβ2-adrenoceptors(EC50valuesare0.43,580and>10000nMforactivationofclonedhumanβ3-,β1-andβ2-adrenoceptorsrespectively).StimulateslipolysisinrhesusADIpocytesinvitro(EC50=3.9nM).EnhancesCRISPR-mediatedhomology-directedrepair(HDR)efficiency2-3-foldforlargefragmentsand~9-foldforpointmutations,inhumaninducedpluripotentstemcells(iPSCs).
L-755,507isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 584.73 |
Formula | C30H40N4O6S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 159182-43-1 |
PubChemID | 9829836 |
InChIKey | NYYJKMXNVNFOFQ-MHZLTWQESA-N |
Smiles | O=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 58.47 | 100 | |
ethanol | 58.47 | 100 |
Thefollowingdataisbasedontheproductmolecularweight584.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.71mL | 8.55mL | 17.1mL |
5mM | 0.34mL | 1.71mL | 3.42mL |
10mM | 0.17mL | 0.86mL | 1.71mL |
50mM | 0.03mL | 0.17mL | 0.34mL |