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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/L-755,507/2197/50/50 mg
产品编号:2197/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/L-755,507/2197/50/50 mg
商品介绍
Description:Verypotentandselectiveβ3partialagoNIST
ChemicalName:4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentβ3-adrenergicreceptorpartialagonist>1000-foldselectiveoverβ1-andβ2-adrenoceptors(EC50valuesare0.43,580and>10000nMforactivationofclonedhumanβ3-,β1-andβ2-adrenoceptorsrespectively).StimulateslipolysisinrhesusADIpocytesinvitro(EC50=3.9nM).EnhancesCRISPR-mediatedhomology-directedrepair(HDR)efficiency2-3-foldforlargefragmentsand~9-foldforpointmutations,inhumaninducedpluripotentstemcells(iPSCs).

CompoundLibraries

L-755,507isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt584.73
FormulaC30H40N4O6S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber159182-43-1
PubChemID9829836
InChIKeyNYYJKMXNVNFOFQ-MHZLTWQESA-N
SmilesO=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO58.47100
ethanol58.47100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight584.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.71mL8.55mL17.1mL
5mM0.34mL1.71mL3.42mL
10mM0.17mL0.86mL1.71mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet