Tocris/SR 1664/4409/50/50 mg,Tocris,,Tocris,Tocris Bioscience,Tocris美元价/进货价 Tocris离子通道调控剂,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Tocris/SR 1664/4409/50/50 mg

产品编号：4409/50

市场价：¥15300.00

场地：美国(厂家直采)

产品分类：生化试剂>生物分子>受体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$765.00

品牌： Tocris

公司：Tocris Bioscience

公司分类：

商品介绍

Description:HighaffinityPPARγligand;blocksCdk5-dependentPPARγphosphorylation

ChemicalName:4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylicacid

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antidiabeticagent;bindstoPPARγandpotentlyinhibitsCdk5-mediatedPPARγphosphorylation(IC₅₀=80nM;K_i=28.67nM)withoutexhibitingPPARγagoNISTactivity.DoesnotinhibitCdk5-dependentphosphorylationofRb.Reducesfastinginsulinlevelsandimprovesinsulinsensitivityinamousemodelofdiabetes.

TechnicalData

M.Wt	547.6
Formula	C₃₃H₂₉N₃O₅
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	1338259-05-4
PubChemID	53239854
InChIKey	IIJDFXNUWZTHIM-NRFANRHFSA-N
Smiles	CC2=C(C)N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C1=CC=C(C(N[C@H](C5=CC=C([N+]([O-])=O)C=C5)C)=O)C=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	54.76	100
	ethanol	54.76	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight547.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.83mL	9.13mL	18.26mL
5mM	0.37mL	1.83mL	3.65mL
10mM	0.18mL	0.91mL	1.83mL
50mM	0.04mL	0.18mL	0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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