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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 144528/5039/50/50 mg
产品编号:5039/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 144528/5039/50/50 mg
商品介绍
Description:HighaffinityandselectiveCB2inverseagoNIST
ChemicalName:5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectiveCB2inverseagonist(Ki=0.6nM).Exhibits>700-foldselectivityforCB2overCB1receptors.BlockstheeffectsofCP55,940(Cat.No.0949)onforskolin-sensitiveadenylylcyclaseactivityandMAPKinCHOcellsexpressingCB2receptors.AlsoblocksCP55,940-inducedB-cellactivation.Orallybioavailable.

TechnicalData

M.Wt476.05
FormulaC29H34ClN3O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber192703-06-3
PubChemID3081355
InChIKeySUGVYNSRNKFXQM-XRHWURSXSA-N
SmilesC[C@]1(C2)[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H]2CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.6100
ethanol47.6100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight476.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.1mL10.5mL21.01mL
5mM0.42mL2.1mL4.2mL
10mM0.21mL1.05mL2.1mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet