HighaffinityandselectiveCB2inverseagonist(Ki=0.6nM).Exhibits>700-foldselectivityforCB2overCB1receptors.BlockstheeffectsofCP55,940(Cat.No.0949)onforskolin-sensitiveadenylylcyclaseactivityandMAPKinCHOcellsexpressingCB2receptors.AlsoblocksCP55,940-inducedB-cellactivation.Orallybioavailable.
M.Wt | 476.05 |
Formula | C29H34ClN3O |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 192703-06-3 |
PubChemID | 3081355 |
InChIKey | SUGVYNSRNKFXQM-XRHWURSXSA-N |
Smiles | C[C@]1(C2)[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H]2CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.6 | 100 | |
ethanol | 47.6 | 100 |
Thefollowingdataisbasedontheproductmolecularweight476.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.1mL | 10.5mL | 21.01mL |
5mM | 0.42mL | 2.1mL | 4.2mL |
10mM | 0.21mL | 1.05mL | 2.1mL |
50mM | 0.04mL | 0.21mL | 0.42mL |