Majormetaboliteofketaminethatisapotentnon-competitiveNMDAreceptorantagonist(Ki=3.6μMfordisplacementof[3H]-MK801inratbrain).Antinociceptiveandanestheticinvivo.R-enantiomerandS-enantiomeralsoavailable.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 260.16 |
Formula | C12H14ClNO.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 79499-59-5 |
PubChemID | 25195026 |
InChIKey | CLPOJGPBUGCUKT-UHFFFAOYSA-N |
Smiles | Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 26.02 | 100 | |
phosphatebufferedsaline | 26.02 | 100 |
Thefollowingdataisbasedontheproductmolecularweight260.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.84mL | 19.22mL | 38.44mL |
5mM | 0.77mL | 3.84mL | 7.69mL |
10mM | 0.38mL | 1.92mL | 3.84mL |
50mM | 0.08mL | 0.38mL | 0.77mL |