Mixedopioidreceptoragonist/antagonist.Actsasapotentandfullagonistatκ,apartialagonistatμandδopioidreceptors(pEC50valuesare9.45,8.74and8.61inacAMPassay,9.70,8.59and8.49ina[35S]GTPγSbindingassayrespectively).FailstoexertagonisteffectsatNOPreceptorsandantagonizesagonist-inducedNOPactivation.Stimulatesκ-,μ-andδ-mediatedanalgesiaandblocksNOP-inducedsupraspinalnociception.
M.Wt | 445.52 |
Formula | C26H27N3O4 |
Storage | Desiccateat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 119630-94-3 |
PubChemID | 9601084 |
InChIKey | AKXCFAYOTIEFOH-XTNAHFASSA-N |
Smiles | O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 22.28 | 50 |
Thefollowingdataisbasedontheproductmolecularweight445.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.24mL | 11.22mL | 22.45mL |
5mM | 0.45mL | 2.24mL | 4.49mL |
10mM | 0.22mL | 1.12mL | 2.24mL |
50mM | 0.04mL | 0.22mL | 0.45mL |