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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/MK 886/1311/50/50 mg
产品编号:1311/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/MK 886/1311/50/50 mg
商品介绍
Description:Inhibitorof5-lipoxygenase-activatingprotein(FLAP)
AlternativeNames:L-663,536
ChemicalName:1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Aninhibitorofleukotrienebiosynthesis(IC50=3nMinhumanpolymorphonuclearleukocytes).Actsbyinhibiting5-lipoxygenase-activatingprotein(FLAP)(IC50=30nMforinhibitionof[125I]-L-691,678photoaffinitylabelling).AlsomoderatelypotentPPARαantagoNIST(IC50=0.5-1μM).Orallyactiveinvivo.

TechnicalData

M.Wt472.08
FormulaC27H34ClNO2S
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber118414-82-7
PubChemID3651377
InChIKeyQAOAOVKBIIKRNL-UHFFFAOYSA-N
SmilesClC(C=C3)=CC=C3CN(C(CC(C)(C(O)=O)C)=C2SC(C)(C)C)C1=C2C=C(C(C)C)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.21100
ethanol2.365

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight472.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.12mL10.59mL21.18mL
5mM0.42mL2.12mL4.24mL
10mM0.21mL1.06mL2.12mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet